Yazar "Bolkent, Sema" için listeleme
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Anti-inflammatory potential of delta-9-tetrahydrocannabinol in hyperinsulinemia: an experimental study
Yazici, Zeynep Mine Coskun; Bilge, Bilgenur; Bolkent, Sema (Springer, 2022)Background Hyperinsulinemia (HI) means that the amount of insulin in the blood is higher than normal and is often associated with type 2 diabetes. It is known that delta-9-tetrahydrocannabinol (THC) obtained from a medicinal ... -
Biochemical and immunohistochemical changes in delta-9-tetrahydrocannabinol-treated type 2 diabetic rats
Coskun, Zeynep Mine; Bolkent, Sema (ELSEVIER GMBH, URBAN & FISCHER VERLAG, 2014)The regulation of glucose, lipid metabolism and immunoreactivities of insulin and glucagon peptides by delta-9-tetrahydrocannabinol (Delta(9)-THC) in diabetes were examined in an experimental rat model. Male Sprague-Dawley ... -
Biochemical and morphologic changes by sitagliptin in diabetic rat liver
Background: The aim of this study was to determine the effects of sitagliptin treatment on type-2 diabetic liver tissue. -
CB-1R and GLP-1R gene expressions and oxidative stress in the liver of diabetic rats treated with sitagliptin
Coskun, Zeynep Mine; Koyuturk, Meral; Karabulut, Sezin; Bolkent, Sema (POLISH ACAD SCIENCES INST PHARMACOLOGY, 2017)Background: Type 2 diabetes is a major health problem affecting millions of people.Controlled eating and regular physical activity are important for the management of type 2 diabetes. Dipeptidyl peptidase-4 enzyme (DPP-4) ... -
Changes in the expression levels of CB1 and GLP-1R mRNAs and microRNAs 33a and 122 in the liver of type 2 diabetic rats treated with ghrelin
Coskun, Zeynep M.; Beydogan, Alisa B.; Bolkent, Sema (Wiley, 2019)The aim of the study is to clarify the effect of ghrelin treatment on the messenger RNA (mRNA) expression of the cannabinoid receptor 1 (Cnr1/CB1) and glucagon-like peptide 1 receptor (Glp1r/GLP-1R) as well as microRNAs ... -
Chronic administration of delta9-tetrahydrocannabinol protects hyperinsulinemic gastric tissue in rats
Colak, Dilara Kamer; Yazici, Zeynep Mine Coskun; Bolkent, Sema (Wiley, 2023)Hyperinsulinemia (HI) can result from some reasons such as an increase in basal/fasting circulating insulin and/or potentiation of postprandial insulin production. Diabetes mellitus (DM) is indirectly related to HI since ... -
The combined ameliorative effects of ?-lipoic acid, selenium, and vitamin E on the livers of STZ-diabetic mice
Kacar, Ayse Karatug; Ertik, Onur; Yazici, Zeynep Mine Coskun; Bolkent, Sema; Yanardag, Refiye; Bolkent, Sehnaz (Istanbul Univ, Fac Pharmacy, 2023)Background and Aims: The aim of this study was to investigate the histological and biochemical effects of the antioxidant combination on liver tissue of streptozotocin (STZ)-induced diabetic mice.Methods: Five groups of ... -
Dipeptidyl peptidase-4 inhibition prevents cell death via extrinsic and intrinsic apoptotic pathways in rat pancreas with insulin resistance
Nephan, Gulay; Coskun, Zeynep Mine; Bolkent, Sema (WILEY, 2018)The study aims to evaluate the effect of saxagliptin, a specific inhibitor of dipeptidyl peptidase-4 enzymes, on body weight gain, lipid profiles, and cell death through apoptosis in rats with insulin resistance (IR). Male ... -
Diyabetik sıçanlara Δ9-tetrahidrokannabinol uygulanmasının serum lipidleri, insulin ve glukagon peptidleri üzerindeki etkileri
Coşkun, Zeynep Mine; Bolkent, Sema (Türk Biyokimya Derneği, 2012)Diabetes mellitus insuline bağımlı olmayan, insulin direnci ile karakterize kronik bir hastalıktır. Diabetes mellitus’da genellikle hiperglisemi ile birlikte hiperlipidemi de gelişir. Cannabis sativa’nın ana psikoaktif ... -
Evaluation of Delta(9)-tetrahydrocannabinol metabolites and oxidative stress in type 2 diabetic rats
Coskun, Zeynep Mine; Bolkent, Sema (MASHHAD UNIV MED SCIENCES, 2016)Objective(s): The object of the study is to examine the effects of Delta(9)-tetrahydrocannabinol (THC) against oxidative stress in the blood and excretion of THC metabolites in urine of type 2 diabetic rats. Materials and ... -
Evaluation of oxidative stress markers in type-2 diabetic rat kidney with treated Δ9-THC
Oxidative stress plays a major role in the pathogenesis of diabetes mellitus. Impaired redox homeostasis can lead to the damage of macromolecules and insulin resistance. Thus, oxidative stress promotes the development of ... -
Evaluation of Δ(9)-tetrahydrocannabinol metabolites and oxidative stress in type 2 diabetic rats.
Coşkun, Zeynep Mine; Bolkent, Sema (Mashhad University of Medical Sciences, 2016)Objectives: The object of the study is to examine the effects of Δ9-tetrahydrocannabinol (THC) against oxidative stress in the blood and excretion of THC metabolites in urine of type 2 diabetic rats. Materials and Methods: ... -
Immunohistochemical, apoptotic and biochemical changes by dipeptidyl peptidase-4 inhibitor-sitagliptin in type-2 diabetic rats
Karabulut, Sezin; Coskun, Zeynep Mine; Bolkent, Sema (POLISH ACAD SCIENCES INST PHARMACOLOGY, 2015)Background: Diabetes is a major public health problem that is rapidly increasing in prevalence. In this study, the effects of sitagliptin, a dipeptidyl peptidase-4 inhibitor, were examined on newborn diabetic rat model. ... -
Influences of calorie restriction and lipopolysaccharide therapy on inflammation, cytokine response, and cell proliferation in pancreatic adenocarcinoma mouse model
Beydogan, Alisa B.; Yazici, Zeynep M. Coskun; Bolkent, Sema (Wiley, 2023)The study aimed to investigate the effects of lipopolysaccharide (LPS) alone and in combination with calorie restriction (CR) on the pancreatic tissues in C57BL/6 mice modeled with pancreatic ductal adenocarcinoma (PDAC). ... -
Oxidative stress and cannabinoid receptor expression in type-2 diabetic rat pancreas following treatment with Δ9-THC
Coşkun, Zeynep Mine; Bolkent, Sema (Wiley Pub., 2014)The objectives of study were (a) to determine alteration of feeding, glucose level and oxidative stress and (b) to investigate expression and localization of cannabinoid receptors in type-2 diabetic rat pancreas treated ... -
Oxidative stress and inflammatory response of ghrelin on myocardial and aortic tissues in insulin-resistant rats
Coskun, Zeynep Mine; Beydogan, Alisa Bahar; Yanar, Karolin; Atukeren, Pinar; Bolkent, Sema (Wiley, 2021)Objectives This study was designed to clarify the effects of ghrelin on myocardial and aortic tissues in insulin-resistant rats. Methods Sprague-Dawley rats were divided into the following groups: control (Group 1), insulin ... -
The protective effects of Delta(9)-tetrahydrocannabinol against inflammation and oxidative stress in rat liver with fructose-induced hyperinsulinemia
Beydogan, Alisa Bahar; Coskun, Zeynep Mine; Bolkent, Sema (WILEY, 2019)Objectives A large amount of fructose is metabolized in the liver and causes hepatic functional damage. Delta(9)-tetrahydrocannabinol (THC) is known as a therapeutic agent for clinical and experimental applications. The ... -
Regulation of gene expression and biochemical changes in small intestine of newborn diabetic rats by exogenous ghrelin
Karatug, Ayse; Sacan, Ozlem; Coskun, Zeynep Mine; Bolkent, Sehnaz; Yanardag, Refiye; Turk, Neslihan; Bolkent, Sema (ELSEVIER SCIENCE INC, 2012)The aim of this study was to investigate (i) the cholecystokinin, somatostatin and apelin mRNA levels, (ii) the changes in levels and localization of these peptides, (iii) relation between these peptides, (iv) anti-apoptotic ... -
Regulation of oxidative stress and somatostatin, cholecystokinin, apelin gene expressions by ghrelin in stomach of newborn diabetic rats
Coşkun, Zeynep Mine; Saçan, Özlem; Karatuğ, Ayşe; Türk, Neslihan; Yanardağ, Refiye; Bolkent, Şehnaz; Bolkent, Sema (Elsevier, 2013)The aim of the study was to determine whether ghrelin treatment has a protective effect on gene expression and biochemical changes in the stomach of newborn streptozotocin (STZ) induced diabetic rats. In this study, four ... -
The role of Δ9-Thc on oxidative stress status of brain and cerebellum in type-2 diabetes
Bolkent, Sema; Coşkun, Zeynep Mine (Society of Cell Membranes and Free Oxygen Radicals, 2014)Diabetes Mellitus is a metabolic disorder characterized by hyperglycemia. The hyperglycemia leads to neuronal damage [1]. The development and progression of diabetes mellitus and its complications are derived from increased ...